OverC-Loop Pro (Overlap Chromatin Loops with Proteins)

The expression of genes is regulated by their promoters, as well as distal regulatory elements (DREs). DREs form chromatin loops with promoters and regulate the expression of genes via long range interactions. 

 

Proteins that bind DREs may have different functions in regulating gene expression that are not mutually exclusive.  For example, they can help in the formation or stabilization of chromatin loops between DREs and gene promoters, as well as they can recruit components of the general transcription machinery.

OverC-Loop Pro enables you to identify the set of DREs and associated promoters that you protein of interest may bind across a diverse set of cell types. Furthermore, OverC-Loop Pro can help you identify other proteins that are working with your protein of interest to form chromatin loops as well as regulate gene expression.

 

If you have a protein of interest that you would like to analyze with  OverC Loop Pro, you can provide us with one of the following:

 

  • The genomic locations where your protein of interest binds.

  • The raw ChIP-seq data for your protein of interest, or other sequencing based methods that identify association of proteins with chromatin

  • Contact us to inquire if we have already found high quality datasets that provide the genomic locations where your protein of interest binds.

 

Please contact us to inquire about how OverC-Loop Pro works, how it can be tailored to your needs, as well as quotes.